All perfect praise be to Allaah, The Lord of the Worlds. I testify that there is none worthy of worship except Allaah, and that Muhammad is His slave and Messenger.
If the hotel does not serve wine or other forbidden items, prevents the guests from committing sins in public and does not allow any acts of dissoluteness, then it is permissible to open it.
The owner of the hotel is not sinful if a guest commits a forbidden act without his knowledge, provided that all possible measures are taken to prevent committing any forbidden acts in the hotel.
Allaah Knows best.