The wife of fugitive Bosnian Serb leader Radovan Karadzic has appealed to him to surrender to the United Nations war crimes tribunal.

In an appeal shown on Bosnian Serb TV, Ljiljana Karadzic urged him to do so for the sake of his family.

Earlier this month, Karadzic's son was held for 10 days by Nato troops.

Karadzic and his military commander during the Bosnian civil war, Ratko Mladic, top the UN tribunal's most-wanted list.

The two men are accused of genocide over the killing of about 8,000 Muslim men during the Srebrenica massacre in July 1995.