Hundred of protesters have run riot in
Groups of demonstrators approached security cordons around the summit, and a bank was set on fire as police fired tear gas to disperse the rioters.
US President George W Bush is one of the leaders present, for discussions which include free trade and poverty.
Bush faces opposition over plans to revive talks on a free trade area.
As the meeting opened, there was no indication that any compromise had been reached.
Poverty
More than 8,000 police have been drafted in to protect the fourth
Protests began peacefully, with thousands of demonstrators chanted "Get out Bush".
They marched through boarded-up streets a few kilometres away from the summit venue itself.
Demonstrators included Argentine former football legend Diego Maradona.
But smaller groups armed with wooden clubs and wearing bandanas began burning US flags, throwing stones and petrol bombs, smashing windows and setting fire to shops.
Police used tear gas to disperse them, and slowing pushing them away from the summit area down one of the town's main streets.
Local media reports said 20 demonstrators had been injured in clashes with police.
Police said 64 people were arrested, and the situation was "under control".
'Defeat imperialism'
Protesters argue that US-backed free-market policies have pushed millions into poverty in the region.
Addressing their rally in a football stadium, Mr Chavez said: "Here, in
He called for help, saying: "Only united can we defeat imperialism and bring our people a better life."
Other demonstrations were held in the Argentine capital
The Venezuelan government has said that it will reject any summit declaration which contains references to free trade in the
However,
Apart from
The rivalry between Bush and Chavez is expected to dominate the meeting.
Asked at a news conference how he would approach Chavez, Bush replied that he would be "polite".
The BBC's South America correspondent Steve Kingstone says the Chavez' growing influence helps explain
Security, democracy and trade are the main areas of interest for the
Washington is concerned about military build-up in Venezuela, suspects it of meddling in Bolivia's election campaign and fears Mr Chavez' talk of closer ties between Latin American nations may attract leaders away from US plans for a huge free trade zone, he adds.
PHOTO CAPTION
A wounded protester is arrested by a plain clothes Argentine policeman during clashes after a demonstration in