Karl Rove, a political adviser to George Bush, the
"I just think it's time," he said in an interview with the newspaper published on Monday.
"There's always something that can keep you here, and as much as I'd like to be here, I've got to do this for the sake of my family."
The newspaper said Rove's resignation as White House deputy chief of staff would become effective on August 31.
Rove, who masterminded president Bush's political campaigns in 2000 and 2004, has been under fire since 2003.
Witness to history
"I'm grateful to have been witness to history," an emotional Rove said on Monday as he appeared side by side with Bush and made his resignation official.
Rove said: "I've seen a man of farsighted courage put
Bush praised him for making "enormous sacrifices" to serve, and in an acknowledgement of his own few days in power, said: "I will be on the road behind you here in a little bit."
Rove said: "I've asked a lot of my family, and they've given all I've asked and more.
"Now it seems the right time to start thinking about the next chapter in our family's life."
Plame affair
Tensions began when Joseph Wilson, a retired
The claim, made by Bush in his 2003 State of the Union address, was widely used to justify the subsequent invasion of
An investigation into the Plame leak led to perjury and obstruction of justice charges, and subsequent conviction of Lewis "Scooter" Libby, a former chief-of-staff for Richard Cheney, the vice-president.
But prosecutors determined last year there was no reason to charge Rove with any wrongdoing.
Asked in the Wall Street Journal interview if he felt he had committed any mistakes during his White House tenure, Rove said: "I'll put my feet up in September and think about that."
PHOTO CAPTION
Karl Rove with president George Bush - 13/8/2007