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The former Bosnian Serb leader, Radovan Karadzic, has been flown from the Serbian capital Belgrade to the war-crimes tribunal in The Hague.
He was moved from a court building where he had been held since his arrest last week, after 13 years on the run.
He has been indicted for crimes against humanity and genocide relating to the Bosnian conflict of the 1990s.
His transfer comes hours after a rally attended by at least 10,000 supporters to protest at his arrest.
Clashes broke out between police and several hundred protesters during the final speeches at the rally organized by the hardline nationalist Radical Party.
Several people were injured as riot police fired tear gas at protesters armed with rocks and burning flares.
Charges
Three cars with tinted windows left the Serbian court building at about 0345 (0145 GMT), with Karadzic inside one of the vehicles. They arrived at the airport 15 minutes later.
The 63-year-old had attempted to challenge the legality of his transfer.
An appeal, posted at the last minute on Friday, had still not been received by the war-crimes court on Tuesday, prompting Serbia's justice minister to issue the final extradition order.
It remains unclear whether the appeal was ever sent.
Karadzic was arrested on 21 July in Belgrade. He had changed his appearance, having grown a long beard and ponytail, and was working as an alternative therapist.
Court appearance
When Karadzic reaches the International Tribunal for the Former Yugoslavia he will be brought to the court's detention unit, and will go through the formality of registration.
He will make an initial appearance in court in the coming days, when he will hear the charges against him. He will be allowed to enter a plea immediately or take 30 days to do so.
Karadzic led the formation of a separate Bosnian Serb assembly in 1991 - one of the sparks that ignited the 1992-1995 Bosnian war.
He has been indicted for crimes against humanity and genocide over the massacre of up to 8,000 mainly-Muslim Bosniaks at Srebrenica in 1995.
He has also been charged over the shelling of Sarajevo, and the use of 284 UN peacekeepers as human shields in May and June 1995.
PHOTO CAPTION
Former Bosnian Serb leader Radovan Karadzic
BBC
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