The opening of the passage of my penis from which urine comes out
is large and sometimes it unfolds and an inner part of it comes out, so is the unfolding of the hole from which urine comes out invalidates ablution, and this happens after urinating, because I know that urine nullifies ablution?

All perfect praise be to Allaah, The Lord of the Worlds. I testify that there is none worthy of worship except Allaah, and that Muhammad is His slave and Messenger. We ask Allaah to exalt his mention as well as that of his family and all his companions.

The mere unfolding of the passage from which urine comes out or other passages, and the appearance of a part of it from the inside of the person's body without any discharges, does not invalidate ablution. 

However, if you are able to treat this medically, then this is better.

Allaah Knows best.